KMID : 0368820090480030168
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Journal of the Korean Neuropsychiatr Association 2009 Volume.48 No. 3 p.168 ~ p.173
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Clinical Characteristics of Bipolar Disorder Patients with Prepubertal Onset - A Pilot Study
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Song Mi-Sun
Kim So-Jung Kim Sun-Young Joo I-Jin
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Abstract
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Objectives: This case-based, small scale study was undertaken to identify the characteristics clinical features of children who exhbiit rare prepubertal onset bipolar disorder.
Methods: We analyzed the clinical records of 13 children who had been hospitalized and diagnosed with bipolar disorder. Clinical characteristics and cognitive function of these patients was based on psychiatrists¡¯ medical records and psychologists¡¯ evaluation reports.
Results: Eleven (84.6%) subjects exhibited clinical features of mixed mania and had a chronic clinical course. They never fulfilled the full criteria of the Diagnostic Statistical Manual of Mental disorders-Fourth Edition (DSM-IV) for manic or hypomanic episodes. Mean age at onset of typical symptoms of bipolar disorder was 9.38 (SD=1.80) and mean age at admission was 12.00 (SD=2.45). Twelve(92.3%) had psychiatric comorbidity. Attention-deficit/hyperactivity disorder was the most prevalent comorbid disease and mean age of onset of it was 6.23 (SD=2.17).
Conclusion: Subjects with prepubertal onset bipolar disorder showed atypical clinical features. These results suggest that most prepubertal onset bipolar disorder patients fail to meet the DSM-IV criteria for typical bipolar¥°disorder and therefore, we need to develop alternative diagnostic criteria for pediatric bipolar disorder.
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KEYWORD
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Bipolar disorder, Prepubertal, Clinical characteristics
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